Two teams hoping to finally put together a winning streak will meet on 'Monday Night Football' as the San Francisco 49ers host the Carolina Panthers . San Fran (7-4) has alternated wins and losses over its last nine games and is coming off a 41-22 victory over Arizona in Week 11. Carolina (6-5) has alternated wins and losses over its last five contests, most recently knocking off Atlanta, 30-27 in overtime, on Sunday. The Niners entered NFL Week 12 ranked seventh in the NFC standings, with the Panthers ninth.

Kickoff is at 8:15 p.m. ET from Levi's Stadium in Santa Clara, Calif. The Niners have won the last two matchups, with the most recent meeting coming in 2022. San Francisco is the 7.5-point favorite in the latest Panthers vs. 49ers odds, while the over/under for total points score

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