Nov 13, 2025; Foxborough, Massachusetts, USA; New England Patriots quarterback Drake Maye (10) hands off the ball to running back Treveyon Henderson (32) against the New York Jets in the third quarter at Gillette Stadium. Mandatory Credit: David Butler II-Imagn Images

Drake Maye and the New England Patriots will face off against the returning Jaxson Dart and the New York Giants on Monday night (8:15 p.m. ET, ESPN).

The Giants' rookie quarterback has missed two games after suffering a concussion against the Bears in Week 10, but is ready to return after clearing concussion protocol. In his absence the Giants' have continued a six-game losing streak - while the first-place Patriots are looking to win their 10th consecutive game this season.

Looking to make a bet on Monday's game? We've got you covered with the latest odds from DraftKings Sportsbook and our prediction for Giants at Patriots.

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Giants at Patriots odds

Provided by DraftKings Sportsbook

  • Moneyline (ML): Patriots -380 (bet $380 to win $100) | Giants +300 (bet $100 to win $300)
  • Against the spread: Patriots -7.5 (+100) | Giants +7.5 (-120)
  • Over/Under (O/U): 46.5 (O: -112 | U: -108)

Giants at Patriots key injuries

Giants

  • OLB Kayvon Thibodeaux (shoulder) out
  • CB Korie Black (biceps) is questionable
  • LB Swayze Bozeman (hip) is questionable
  • OLB Victor Dimukeje (knee) is questionable
  • LB Demetrius Flannigan-Fowles (knee/neck) is questionable
  • DL Dexter Lawrence (elbow) had limited participation in practice

Patriots

  • G Jared Wilson (ankle) is out
  • S Brenden Schooler (ankle) is out
  • LB Harold Landry (knee) is questionable
  • DT Khyiris Tonga (chest) is questionable

Giants at Patriots picks and predictions

Prediction

Patriots 28, Giants 24

Against the spread

Play the Giants +7.5 (-120) on the road. The Giants have already been eliminated from playoff contention, while the Patriots are looking to head into a bye week at 11-2. These teams are clearly going in opposite directions - but there's no pressure on the Giants in Dart's return game, and these Giants have made a habit of losing close games.

In games where the Giants have been a full touchdown (or more) underdog in 2025, New York is 4-1 against the spread. The Patriots are 1-3 against the spread in their last four games, and failed to cover big spreads against the Jets and Bengals in recent weeks.

Over/Under

Over 46.5 (-112) is the safer total play on Monday. The over has hit in six of the last seven Giants games, and the New York offense should be more dangerous under Dart than it has been under Jameis Winston. Dart has rushed for a touchdown in five consecutive starts.

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This article originally appeared on For The Win: Giants vs. Patriots prediction, latest odds from DraftKings Sportsbook

Reporting by Nick Schwartz, For The Win / For The Win

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