Flipping The Switch And Turning On New Sickle Cell And Thalassemia Therapies

A new chapter is unfolding for patients with sickle cell disease and beta-thalassemia: breakthroughs in gene regulation are transforming how these conditions are treated. Emerging approaches focus on turning fetal hemoglobin back on by blocking the molecular “off switch” that normally silences it after birth Image by freepik

A new chapter is unfolding for patients with sickle cell disease and beta-thalassemia: breakthroughs in gene regulation are transforming how these conditions are treated. Emerging approaches focus on turning fetal hemoglobin back on by blocking the molecular “off switch” that normally silences it after birth. These directly target the regulatory pathways controlling hemoglobin expression. With the potential to reduce painful crises, organ damage and transfus