Louisville Cardinals guard Ryan Conwell (3) dribbles against NJIT Highlanders guard Ari Fulton (24) during the second half at KFC Yum! Center. Louisville defeated New Jersey Tech 104-47 in Louisville, Kentucky.

The No. 6 Louisville Cardinals (7-0) face the No. 23 Arkansas Razorbacks (5-2) Wednesday in the ACC/SEC Challenge. Tip-off from at Bud Walton Arena in Fayetteville, Arkansas, is set for 7:15 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NCAA basketball odds around the Louisville vs. Arkansas odds and make our expert college basketball picks and predictions for the best bets.

The Cardinals are coming off a 104-47 laugher as 44-point favorites against the New Jersey Institute of Technology Highlanders last Wednesday. G Ryan Conwell drilled 8 threes en route to 32 points. He has gone for 22+ in 4 of 5 games. Louisville has had a cupcake schedule thus far, but covered as 6-point favorites against the Kentucky Wildcats in a 96-88 win Nov. 11.

Arkansas presents a different challenge as coach John Calipari renews his rivalry with the Cardinals from his days at UK. Louisville fell 80-71 at a neutral site against the Duke Blue Devils Thursday. They managed to cover as 12-point dogs, though. G Darius Acuff stepped up with 21 points on 4-for-8 shooting from downtown. F Trevon Brazile had 11 points and 11 boards.

Arkansas won 80-54 as 15.5-point favorites in the last meeting Nov. 21, 2022, at Lahaina Civic Center in Hawaii.

– Rankings: USA TODAY Sports Coaches Poll

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Louisville at Arkansas odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:42 p.m. ET.

  • Moneyline (ML): Louisville -145 (bet $145 to win $100) | Arkansas +118 (bet $100 to win $118)
  • Against the spread (ATS): Louisville -2.5 (-110) | Arkansas +2.5 (-110)
  • Over/Under (O/U): 165.5 (O: -110 | U: -110)

Louisville at Arkansas picks and predictions

Prediction

Louisville 91, Arkansas 81

Moneyline

I'm with Louisville here, but I'd rather lay the points. Instead, take RYAN CONWELL OVER 19.5 POINTS (-115). As mentioned, he has done this in 4 of 5.

Against the spread

Take LOUISVILLE -2.5 (-110). The Cardinals are 5-2 ATS this season with their only ATS losses being as 31.5-point and 39-point favorites.

Over/Under

Louisville is 3-4 O/U this season, and Arkansas is 2-5. Throw these out the window, though, because of the weak early season competition. Louisville is fourth in the country at 96.7 PPG, and Arkansas is tied for 45th at 88.1 PPG.

Give me OVER 165.5 (-110).

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This article originally appeared on Sportsbook Wire: Louisville Cardinals at Arkansas Razorbacks odds picks and predictions

Reporting by Ryan Dodson, Sportsbook Wire / Sportsbook Wire

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