The internet can’t resist Great Dane mixes—and Newsweek’s most-read gentle-giant stories prove it.

From unlikely pairings and DNA-test curveballs to rescue surprises, these five viral articles show that oversized dogs with unexpected origins keep stealing the spotlight.

Here are the top five stories about Great Dane mixes that stole our readers hearts in 2025:

1. Great Dane and Gray Wolf Have Puppies

This story starts like a rescue update and ends like a jaw-drop. Macie, a lanky, frightened shelter dog in Florida, was pulled from a euthanasia list by rescuer Rebecca Landerman after being labeled too stressed to stay in the shelter. Once safe, her long legs and slim build sparked curiosity about her breed—so Landerman ordered a DNA test.

The results shocked even experienced wolfdog

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