Key Takeaways

Laughing gas might be a powerful, fast-acting treatment for depression

People treated with nitrous oxide experienced quick relief from depression symptoms

Repeated doses provided durable benefits

MONDAY, Dec. 8, 2025 (HealthDay News) — Laughing gas might live up to its name for people struggling with depression , a major new study says.

Treatment with nitrous oxide can provide rapid relief for people with depression, especially those who aren’t helped by antidepressants, researchers reported recently in the journal eBioMedicine .

“This is a significant milestone in understanding the potential of nitrous oxide as an added treatment option for patients with depression who have been failed by current treatments,” senior researcher Dr. Steven Marwaha , an academic p

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