Key Takeaways

In a review of nearly 120,000 patients, 31% taking opioids developed C. diff , compared to 17% not taking them

Opioids may weaken immunity and disrupt healthy gut bacteria, making infection more likely

Experts say those prescribing opioids should consider individual needs and risks

WEDNESDAY, Dec. 10, 2025 (HealthDay News) — Taking opioids may make some patients more likely to develop a dangerous infection, new research suggests.

The infection is called Clostridioides difficile , or C. diff . It affects the colon and can spread easily, especially in hospitals and nursing homes. The illness can cause severe diarrhea, stomach pain, nausea and vomiting. In serious cases, it can lead to life-threatening complications.

About 500,000 Americans get C. diff each year,

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