By Week 15, the margins get thin in fantasy football and every lineup choice carries playoff weight.

Matchups sharpen, roles stabilize and small edges can swing entire seasons.

These are the plays and fades you need this week.

Quarterbacks

Start: Brock Purdy, 49ers vs. Titans

Purdy draws one of the most favorable quarterback matchups of Week 15. Tennessee’s coverage unit has struggled to contain layered route concepts and timing-based passing game — exactly the structure of San Francisco’s offense. With the 49ers’ run game forcing defensive overcommitment and Purdy excelling in rhythm throws, the Titans’ inability to generate consistent pressure creates a clean environment for efficient, high-value production. Purdy carries legitimate QB1 upside this week.

Other locks:

— Joe Burrow

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