Arguably the best matchup on Sunday's Week 15 NFL slate comes in the late afternoon window when the Detroit Lions head out west to face the Los Angeles Rams, bringing Jared Goff and Matthew Stafford face to face with their old franchises. The trade famously gave Stafford and the Rams a Super Bowl win in 2021 but helped Detroit build a contender as well.

The Lions have won the last two games in this series, but the Rams are 6-point favorites in the latest Lions vs. Rams odds from DraftKings . The total sits at 55. Kickoff from SoFi Stadium in Los Angeles is set for 4:25 p.m. ET. Before making any Rams vs. Lions picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times.

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