CNN —

About two years ago, celebrity cosmetic dermatologist Dr. Paul Jarrod Frank noticed a new type of patient arriving at his New York practice. Amid an explosion in the number of Americans losing weight with drugs like Ozempic, he saw a "dramatic spike" in clients experiencing unwelcome side effects.

"Although they felt much better losing weight, in some ways they felt they looked older," he said via a voice note. "And this was due to the loss of volume in their face."

Frank started using the term "Ozempic face" — a label he believes he coined — to describe the phenomenon. It has since become a social media byword for the sagging skin and hollowed-out appearance that can accompany the use of GLP-1 medications like semaglutide (the active ingredient in branded drugs such as Ozempic an

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