Detroit Tigers pitcher Casey Mize (12) throws against Arizona Diamondbacks during the first inning at Comerica Park in Detroit, Michigan.

The Minnesota Twins (52-59) visit the Detroit Tigers (65-48) Monday in the first game of a 3-game series. First pitch from Comerica Park is at 6:40 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Twins vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

Season series: Tigers lead 4-2

The Twins are in fourth place in the AL Central, 12 games behind the Tigers and 7 games back in the Wild Card race. They closed out their series against the Cleveland Guardians Sunday with a 5-4 win to snap a 4-game losing streak. They scored 4 runs in the top of the first inning and held on as the Guardians scored 2 in the ninth. After SP Jose Urena only went 4 innings, RP Kody Funderburk pitched 2 scoreless inning to pick up the win. RP Erasmo Ramirez got the final 2 outs for his first save as the fifth reliever in the game.

The Tigers have an 8-game lead over the second-place Guardians in the AL Central. They have won 5 of their last 7 games, but are coming off a 2-1 series loss on the road to the Philadelphia Phillies. They lost the finale Sunday 2-0 as they mustered only 5 hits against Phillies starter Cristopher Sanchez (8 IP, 5 H, 1 BB, 6 K) and reliever Jhoan Duran, who pitched the ninth inning to pick up his second save. In his first start following his trade to Detroit, SP Charlie Morton went 6 innings, allowing only 1 run on 4 hits, walking 1 and striking out 6.

Twins at Tigers projected starters

RHP Simeon Woods Richardson vs. RHP Casey Mize

Woods Richardson (5-4, 4.24 ERA) makes his 17th start and 18th appearance. He has a 1.40 WHIP, 3.9 BB/9 and 7.7 K/9 through 80 2/3 innings.

  • Last start: No-decision, 4 2/3 IP, 3 ER, 7 H, 2 BB, 5 K in 5-4 home win over the Boston Red Sox last Monday
  • Last start vs. Tigers (April 13): Win, 5 IP, 1 ER, 5 H, 0 BB, 5 K in 5-1 win in Detroit
  • Career vs. Tigers: 2-1, 2.91 ERA (21 2/3 IP, 7 ER), 0.88 WHIP, 7.1 K/9 in 4 starts
  • 2025 road splits: 1-2, 5.30 ERA (35 2/3 IP, 21 ER), 1.57 WHIP. 7.8 K/9 in 7 starts and 1 relief appearance

Mize (9-4, 3.43 ERA) makes his 19th start. He has a 1.33 WHIP, 2.5 BB/9 and 8.0 K/9 through 94 1/3 innings.

  • Last start: No-decision, 1 2/3 IP, 1 ER (2 R), 3 H, 3 BB, 2 K in 12-2 home win on Tuesday
  • Last start vs. Twins (June 28): Win, 6 2/3 IP, 2 ER, 5 H, 1 BB, 5 K in 10-5 win in Detroit
  • Career vs. Twins: 2-4, 4.91 ERA (44 IP, 24 ER), 1.30 WHIP, 7.2 K/9 in 9 starts
  • 2025 home splits: 5-1, 3.32 ERA (40 2/3 IP, 15 ER), 1.21 WHIP, 7.7 K/9 in 8 starts

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Twins at Tigers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:59 a.m. ET.

  • Moneyline (ML): Twins +135 (bet $100 to win $135) | TIgers -160 (bet $160 to win $100)
  • Run line (RL)/Against the spread (ATS): Twins +1.5 (-170) | Tigers -1.5 (+140)
  • Over/Under (O/U): 8.2 (O: -102 | U: -118)

Twins at Tigers picks and predictions

Prediction

Tigers 6, Twins 4

Moneyline

The Tigers are 36-21 at home and have won 4 straight games at Comerica Park, averaging 8.5 runs per game in that stretch. The Twins are 22-35 on the road and 29-42 against teams over .500.

Expect the Tigers to win the opener, but -160 odds don't have the value the run line has, especially when the Tigers typically win by more than 1 run.

PASS.

Run line/Against the spread

Twenty-one of the Tigers' last 24 wins have been by more than 1 run.

The Twins are a good bet as road dogs at 24-12 ATS, but the Tigers' 19-16 ATS mark as home favorites isn't terrible.

BET TIGERS -1.5 (+140).

Over/Under

Only 2 of the 6 meetings between the teams this season have surpassed 8 total runs, but 7 of the last 8 games for the Twins have had totals of 9 runs or more, and 5 of the last 7 games for the Tigers, including 4 of their last 5 wins, have reached at least 9 total runs.

BET OVER 8.5 (-102).

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This article originally appeared on Sportsbook Wire: Minnesota Twins at Detroit Tigers odds, picks and predictions

Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect