Paddy Lowe left his role as Mercedes' executive technical director ahead of 2017 and moved to Williams.
But Mercedes still earned a fourth straight F1 title double, with James Allison heading up a chassis team including Aldo Costa, Geoff Willis, Mark Ellis and John Owen, and Andy Cowell remaining in charge of its engine division.
Wolff said Mercedes had put huge emphasis on in-house staff development so that it was not vulnerable whenever any big-name technical personnel moved on.
"In the Formula 1 team, because of the ever-changing regulatory environment and the challenges you face, it is not a static structure, it is dynamic," Wolff told Motorsport.com.
"You can't freeze an organisation because it is successful. You need to look after the next generation of leaders, you need to adapt