Nike co-founder Phil Knight is donating $2 billion to the Oregon Health and Science University's Cancer Institute, the single largest donation ever to a U.S. university, college or health institution, according to the Knight Foundation.

The foundation said on Thursday the gift that will be used to shift the scientific approach to cancer treatment, research and patient care outcomes.

As part of the gift, the Knights will partner with cancer research pioneer Dr. Brian Druker.

A decade ago, Druker and OHSU took on a challenge to raise $500 million for cancer research, and the Knights signed on to match the raise dollar-for-dollar.

"We are grateful for the opportunity to invest in the next stage of the Druker-led revolutionary vision of cancer research, diagnosis, treatment, care,

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