The optimal strategy for treating newly diagnosed high-risk prostate cancer remains unclear. More specifically, do these patients benefit more from radical prostatectomy or a radiotherapy-based approach?

A recent analysis aimed to help clarify the uncertainty.

The study , which evaluated individual patient data from two large contemporary randomized controlled trials, appeared to favor a radiotherapy-based treatment strategy over a surgery-based approach in this patient population. Compared with radical prostatectomy followed by personalized postoperative therapy, radiotherapy plus androgen deprivation therapy (ADT) was associated with a 32% relative reduction in distant metastases at 8 years.

However, the risk for death after distant spread was similar between the two strategies.

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