A tour bus returning to New York City from Niagara Falls with more than 50 passengers crashed and rolled Friday on an interstate highway, killing and injuring multiple people, police said.

The bus apparently lost control on I-90 near Pembroke, N.Y., about 40 kilometres east of Buffalo. People inside were ejected as the windows shattered.

"At this time we have multiple fatalities, multiple entrapments and multiple injuries," said Trooper James O'Callahan, a spokesperson for the New York State Police.

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