A Big 12 battle kicks off the Week 0 college football schedule when the Kansas State Wildcats take on the Iowa State Cyclones in the 2025 Aer Lingus College Football Classic in Dublin, Ireland. The Cyclones have dominated this series in recent years, winning four of the last five meetings against Kansas State. Iowa State recorded a 29-21 victory over Kansas State last season, covering the spread as 2-point favorites. Both starting quarterbacks have returned in 2025, with Rocco Becht for Iowa State and Avery Johnson for Kansas State.

Kickoff from Aviva Stadium in Dublin is set for noon ET. Kansas State is favored by 3 points in the latest Kansas State vs. Iowa State odds at bet365, while the over/under for total points scored is 51. Before making any Iowa State vs. Kansas State picks, be s

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