The No. 22 Iowa State Cyclones kick off their 2025 season against the Big 12 Conference rival No. 17 Kansas State Wildcats in a Week 0 matchup in Ireland on Saturday. Iowa State shared the regular-season Big 12 championship, while Kansas State shared eighth-place in the conference with West Virginia. The Wildcats (5-4, 9-4), who were 2-1 against ranked opponents a year ago, had a plus-97 point differential. The Cyclones (11-3, 7-2), who were 9-2 against unranked foes, were plus-114 in point differential. This is the first ranked matchup between these programs since 2002.

Kickoff is set for noon ET at Aviva Stadium in Dublin, Ireland. Iowa State leads the all-time series 54-50-4, including a 29-21 win last season. KSU is the 3-point favorite in the latest Iowa State vs. Kansas State

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