The 2025 college football season has finally arrived, with the Week 0 college football schedule taking place on Saturday. The slate is headlined by a noon ET Big 12 matchup between No. 17 Kansas State and No. 22 Iowa State in Dublin, Ireland, which is hosting a college football game for the 10th time. Kansas State is the pre-season favorite in the Big 12 (+500), and the Wildcats are 3-point favorites in the latest Week 0 college football odds. This is the first ranked matchup between these programs since 2002.

Other Week 0 college football spreads involving Power Four teams are Kansas (-14) against Fresno State and Hawaii (-2.5) against Stanford in the nightcap on CBS. Western Kentucky (-10) vs. Sam Houston, which is on CBS Sports Network, is the other matchup on the slate in a battle of

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