SANTA CLARA, Calif. -- The San Francisco 49ers open the 2025 regular season against the Seattle Seahawks on Sept.7 at Lumen Field (4:05 p.m. ET).

After missing the playoffs last season, the 49ers underwent a massive roster overhaul, creating more competition than it has had for spots on the depth chart than at any point in the past six years. While the stars -- tight end George Kittle , offensive tackle Trent Williams , running back Christian McCaffrey , defensive end Nick Bosa and linebacker Fred Warner -- remain, much of San Francisco's success this season will hinge on how some of the unfamiliar names come along.

The roster will be cut to 53 players by 4 p.m. ET on Tuesday. Here is a projection:

QUARTERBACKS (2): Brock Purdy , Mac Jones

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