Joey Pollizze analyzes all 2025 fantasy football Week 1 defenses (DEF) -- streamers, sits/starts, and D/ST waiver wire pickups to add. His Week 1 rankings and tiers for all of the NFL defenses.

Welcome, RotoBallers, to our first weekly defensive rankings article. Every week of the fantasy football season, this article will contain the best and worst defensive options. Each defense will be ranked No. 1 through No. 32 every week until the end of the fantasy football season. This will be your go-to stop for all defensive rankings and streamers.

The first week is always the toughest to rank these defenses because both offenses and defenses changed in the offseason. Most of these teams have new play-callers, and plenty of players have switched teams. However, there is a lot of information at

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