The incident happened around 2:15 p.m. on Page Street near the intersection of York Street, according to officials with Virginia State Police.
"Preliminary investigations indicate that the 40-year-old male scooter operator was possibly struck by a vehicle that may have left the scene," troopers said.
The scooter driver, who suffered what were described as serious injuries, was medflighted to VCU Medical Center in Richmond.
Officials said no description of the vehicle or where it was headed was available Sunday evening.
"The Virginia State Police Crash Reconstruction Team is assisting with the ongoing investigation," officials said.
Anyone who witnessed the crash, noticed suspicious activity in the area or has information that could assist investigators is asked to call Virginia State