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College football picks, predictions against the spread for Week 1 matchups

Three top-10 showdowns are the highlight of the Week 1 schedule – and an immediate chance to show we can pick the big game.

No. 1 Texas is a road underdog at No. 3 Ohio State. The Longhorns and Buckeyes clash at noon on FOX. No. 4 Clemson takes on No. 9 LSU at 7:30 p.m. on ABC. On Sunday, No. 6 Notre Dame takes on No. 10 Miami. The Irish are a road favorite.

Sporting News 2025 Preseason All-America Team

There are 13 games involving FBS teams in Week 1. There are more games with spreads of 22.5 points or more than single-digit spreads, which makes for a challenge.

Each week, we pick games against the spread for AP Top 25 teams. Nine Top 25 teams play FCS opponents this week. We don't pick

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