The Penn State Nittany Lions will host the Nevada Wolf Pack in a 2025 Week 1 college football showdown on Saturday. The Big Ten side was a surprise success last season, going 13-3 overall with a 7-1 home record and 8-1 mark in conference play. They will host a Mountain West squad looking to rebound from a dismal 3-10 2024 season that ended with six straight losses.

Kickoff from Beaver Stadium is set for 3:30 p.m. ET. The Nittany Lions are 43.5-point favorites in the latest Nevada vs. Penn State odds from SportsLine consensus, while the over-under for total points scored is set at 55.5. Before making any Penn State vs. Nevada picks or same-game parlays, be sure to see the Week 1 college football predictions from SportsLine's proven model and check out the latest college football odds

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