Mike's Week 2 college football betting picks against the spread for Friday, September 5, 2025. Free CFB betting predictions, odds analysis, and ATS picks from RotoBaller.

We had a huge weekend of college football to open the 2025 season over Labor Day. Most of the big games were good games. We had a few upsets. We saw a couple of FCS schools collect scalps.

Tarleton State knocked off Army in double overtime. Austin Peay beat Middle Tennessee State by 20 points. Even Kent State snapped its 21-game losing streak with a win over Merrimack. Alabama State gave UAB all it could handle. A couple of Group of 5 powers were knocked off as well.

We have another loaded weekend with 83 total games on Friday and Saturday. Four games are on Friday, but only two feature FBS vs. FBS teams. I don't pick

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