Aug 9, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) warms up before the game against the Denver Broncos at Levi's Stadium.

The San Francisco 49ers added Christian McCaffrey to their injury report Thursday after the veteran running back was a full participant in Wednesday's practice.

McCaffrey was downgraded to limited because of a calf injury, according to the 49ers' official injury report.

McCaffrey missed the first eight games of the 2024 NFL season while dealing with Achilles tendinitis. The 29-year-old was only able to play in a total of four games after returning and suffering a PCL sprain in his knee during a Week 13 loss to the Buffalo Bills.

Christian McCaffrey injury update

The 49ers have not provided additional clarity on whether McCaffrey's practice downgrade was simply a precaution or if he is dealing with a new injury. His status at Friday's practice could be telling about his availability for the team's Week 1 game against the Seattle Seahawks.

49ers RB depth chart

If McCaffrey is unable to play in Week 1 because of his injury, the 49ers would likely rely on Brian Robinson Jr. and Isaac Guerendo to lead their backfield.

Robinson was acquired from the Washington Commanders in a preseason trade. The 6-1, 228-pound back racked up 799 yards and eight touchdowns for his former team. Meanwhile, Guerendo totaled 420 yards and four touchdowns as a rookie for the 49ers last season.

Below is a full look at San Francisco's running back depth chart:

  1. Christian McCaffrey
  2. Brian Robinson Jr.
  3. Isaac Guerendo
  4. Jordan James
  5. Sincere McCormick (practice squad)

(This story will be updated as more information becomes available.)

This article originally appeared on USA TODAY: Christian McCaffrey injury update: 49ers RB a limited participant in practice

Reporting by Jacob Camenker, USA TODAY / USA TODAY

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