There is a heavy divisional slate to begin the 2025 NFL season with half of the 16 matchups being such contests. The entire NFC North will battle one another with Packers vs. Lions having Green Bay as 2-point favorites, per the Week 1 NFL odds , before Bears vs. Vikings (-1.5) on Monday night. While these rivalry games will certainly elicit high interest with Week 1 NFL bets, one of the most anticipated showdowns is a non-divisional contest. On Sunday night we'll see a rematch from last season's playoffs, as the Bills will host the Ravens.

The game will feature MVP winner, Josh Allen, and the runner-up in Lamar Jackson, as the Ravens look for redemption from their heartbreaking playoff defeat. Buffalo was a 1.5-point underdog in that Divisional Round game, and the latest Week 1 NFL line

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