The Tampa Bay Buccaneers and Atlanta Falcons start the 2025 NFL regular season in an NFC South showdown in Week 1. Last season, Tampa Bay logged a 10-7 record and won the division. The Falcons finished in second place with an 8-9 campaign. However, the Falcons swept the season series in 2024, including a 36-30 overtime win over Tampa Bay at home.

Kickoff from Mercedes-Benz Stadium is set for 1 p.m. ET on Sunday, Sept. 7. Tampa Bay is favored by 2.5 points in the latest Buccaneers vs. Falcons odds at bet365 Sportsbook, while the over/under for total points scored is 47.5. Before making any Falcons vs. Buccaneers picks or same-game parlays, be sure to see the Week 1 NFL predictions from SportsLine's proven model and check out the latest NFL odds . Bet on Buccaneers vs. Falcons at bet365,

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