The Week 1 NFL schedule is finally here, and several teams will be looking to make a statement with an early-season victory. The Green Bay Packers made the playoffs in 2024 but were ousted by the Philadelphia Eagles in the Wild Card Round. Green Bay opens the 2025 NFL season with an NFC North showdown against the Detroit Lions on Sunday at 4:25 p.m. ET. Green Bay is 1-6 in its last seven meetings against Detroit, but the Packers are 2.5-point favorites, according to the latest Week 1 NFL odds . SportsLine's model is backing Green Bay, which is 10-4 in its last 14 games at home, to handle business at Lambeau Field and cover the spread in well over 50% of simulations.

The model is also backing the Jaguars (-3.5) to cover at home against the Panthers, while the Over (45.5) hits in well ove

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