Week 1 of the NFL season is often the healthiest nearly every team will be in the NFL season, but this year 49ers star running back Christian McCaffrey (calf) is opening the season with a questionable tag. When McCaffrey's on the field, he's one of the most profitable players for NFL player prop bets. He's often a touchdown machine and a high-volume runner, and if he's able to go, McCaffrey going Over 71.5 rushing yards is one of the SportsLine model's best bets for Week 1 NFL player prop picks when online sports betting . McCaffrey's over/under for total rushing attempts is 14.5 when the 49ers battle the Seahawks at 4:05 p.m. ET.

Targeting NFL player props is a popular way to approach Week 1 NFL betting . With NFL props available for almost every player in every game, SportsLine's

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