The 2025 NFL season continues Sunday, and while you can always wager on spreads, totals and player props offered at or near the typical -110 odds line, there are ample longshot plays available across every sportsbook to boost your payday. The longer the odds, the bigger the risk, but it also means the larger the payday. And with the SportsLine model, there are some longshots involving some of the most important players in the NFL that project value to include when online sports betting the Week 1 NFL schedule.

One of the model's favorite longshot plays for Week 1 NFL bets is Cardinals Kyler Murray to throw for at least 260 yards on DraftKings Sportsbook. Murray's passing yards over/under at DraftKings is set for 222.5, but the model projects the best value of taking him at 260+ odds for

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