In the 2025 NFL season opener between the Baltimore Ravens and the Buffalo Bills , Derrick Henry ‘s fumble late in the fourth quarter proved to be a pivotal moment in the game’s outcome. With 3:06 remaining and the Ravens leading 40–25, Henry lost control of the ball during a run, allowing the Bills to recover and capitalize on the turnover. This miscue shifted the momentum in favor of Buffalo, who subsequently scored and completed a successful two-point conversion, narrowing the Ravens’ lead to 40–33. The Bills then executed a game-winning drive, culminating in a 32-yard field goal as time expired, securing a 41–40 victory.
Following the game, Henry took full responsibility for the fumble, stating, “ I told my teammates after the game to put the loss on me. I own it like a man. ”