The San Francisco 49ers were hoping to stay healthy this season. Last year, they couldn't buy a stroke of good luck on the injury front.

Unfortunately, with the 2025 NFL season just one week in, the 49ers are already dealing with an injury crisis.

George Kittle, the team's star tight end, will miss at least the next four games after being placed on injured reserve due to a hamstring injury. There is even concern about San Francisco having to play without star quarterback Brock Purdy in Week 2.

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Purdy is dealing with a left shoulder injury. He is also dealing with a toe injury as well. Those are not things teams want their starting quarterback working through after just one game.

With that being said, one former NFL quarte

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