Notre Dame Fighting Irish quarterback CJ Carr (13) smiles during warmups before a game against the Texas A&M Aggies at Notre Dame Stadium in South Bend, Indiana.

The Purdue Boilermakers (2-1) and the No. 21 Notre Dame Fighting Irish (0-2) meet Saturday. Kickoff from Notre Dame Stadium in Notre Dame, Indiana, is scheduled for 3:30 p.m. ET (NBC / Peacock). Let's analyze BetMGM Sportsbook's NCAA football odds around the Purdue vs. Notre Dame odds and make our expert college football picks and predictions for the best bets.

After winning its first 2 games, Purdue lost 33-17 to USC Sept. 13. It covered as a 20.5-point home underdog and the Under (59.5) hit. QB Ryan Browne went 24-of-39 for 305 yards with a TD and 3 INTs while adding a score on the ground. The Boilermakers rushed for just 52 yards in the loss.

Notre Dame remains winless after falling 41-40 to Texas A&M Sept. 13. It failed to cover as a 6.5-point home favorite and the Over (50.5) cashed. QB CJ Carr went 20-of-32 for 293 yards with a TD and an INT. RB Jeremiyah Love rushed 23 times for 94 yards and a TD and caught 4 passes for 53 yards and another score.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

Purdue at Notre Dame odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 5 p.m. ET.

  • Moneyline (ML): Purdue +1400 (bet $100 to win $1,400) | Notre Dame -5000 (bet $5,000 to win $100)
  • Against the spread (ATS): Purdue +24.5 (-105) | Notre Dame -24.5 (-115)
  • Over/Under (O/U): 51.5 (O: -105 | U: -115)

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Purdue at Notre Dame picks and predictions

Prediction

Notre Dame 34, Purdue 10

Moneyline

PASS.

There is no value on Notre Dame (-5000) to get its first win Saturday at home.

Against the spread

LEAN PURDUE +24.5 (-105).

The Boilermakers have scored at least 17 points in each of their 3 games this season and face a Fighting Irish team that has struggled mightily.

Notre Dame's defense has allowed 27 or more points in both games this season. It will have an easier task against the Boilermakers, but any scoring will make it a tall task to cover such a wide spread.

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Over/Under

BET UNDER 51.5 (-115).

Purdue struggled offensively last week against USC, scoring just 17 points. It has not shown a flashy offense, even against lesser teams like Southern Illinois. The Boilermakers will struggle to move the ball against the Fighting Irish.

Notre Dame is facing its easiest opponent so far and will look to make the most of the opportunity in front of its home crowd. Expect the Fighting Irish defense to lead the way in this matchup.

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This article originally appeared on Sportsbook Wire: Purdue Boilermakers at Notre Dame Fighting Irish odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

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