The Guardians open a four-game series against the rebuilding Twins on Friday night. They are 6-3 against the Twins this year, but the Twins have outscored them, 35-33.
Guardians, Minnesota Twins starting lineups for Sept. 19, 2025: Game 153

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The Guardians open a four-game series against the rebuilding Twins on Friday night. They are 6-3 against the Twins this year, but the Twins have outscored them, 35-33.