The Indianapolis Colts meet the Tennessee Titans in NFL Week 3 action. The Colts want to keep rolling after starting with two wins for the first time since 2009, but this is their first road game. The Titans (0-2) are struggling through a rebuilding process with a No. 1 overall draft pick, quarterback Cam Ward .

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What time does Tennessee Titans-Indianapolis Colts game start today, Sunday, Sept. 21, 2025? When is Colts-Titans NFL football game tonight?

The Indianapolis Colts and Tennessee Titans will play at 1 p.m. ET Sunday, Sept. 21, 2025. Watch Colts-Titans NFL Week 3 action with Fubo Expert MLB daily picks: Unique MLB betting insights only at USA TODAY

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