Week 4 of the 2025 NFL season begins with Cardinals vs. Seahawks on Thursday Night Football and kickoff is scheduled for 8:15 p.m. ET. Seattle is a 1.5-point favorite while the over/under is at 43.5 points, and both these defense are top five in the NFL in points allowed through three weeks. With that in mind, under 43.5 points is one of our top NFL picks today and we've also got picks from the MLB and La Liga that can help tide you over until the big game tonight.

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