Duke football takes its first ACC road trip to Syracuse for a Week 5 contest on Saturday, Sept. 27, at the JMA Wireless Dome against the Orange .

The Blue Devils (2-2, 1-0 ACC) and Orange (3-1, 1-0) will kick off at 12 p.m. ET in a game that will be televised on ACC Network and can be streamed via Fubo (free trial) .

Duke is coming off a 45-33 win over N.C. State to open conference play. It is up against a Syracuse team that is coming off a 34-21 road win at Clemson in Week 4.

The Blue Devils are 4-1 overall against the Orange and 3-0 when playing them on the road. Duke is looking for its second straight win over Syracuse after a 38-24 road victory in 2020.

Here are picks, predictions and odds for Duke's Week 5 matchup at Syracuse.

Duke vs Syracuse odds, money line, over/under

Odds c

See Full Page