The San Francisco 49ers have a chance to start the season with a 4-0 record, but the Jacksonville Jaguars stand in their way. Brock Purdy seems to be trending toward a return for the 49ers offense, and it will be in the nick of time, given the Jaguars’ defensive line. Robert Saleh and the 49ers defense will attempt to replace Nick Bosa’s impact on defense against Liam Coen and the Jaguars’ offense.

Here are three matchups to keep an eye on Sunday.

Jaguars’ rushing attack vs 49ers’ run defense

Travis Etienne is in top form through three weeks, averaging nearly six yards per carry with 270 rushing yards. Bhayshul Tuten has been a potent option following Tank Bigsby’s departure via trade to Philadelphia, with 74 yards on 17 attempts and 60 yards after contact. Etienne has forced eight miss

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