USC Trojans quarterback Jayden Maiava (14) throws a pass during the first half against the Georgia Southern Eagles at United Airlines Field at Los Angeles Memorial Coliseum.

USC football will have a real prove-it game against No. 23 Illinois on Saturday, Sept. 27.

The No. 22-ranked Trojans (4-0, 2-0 Big Ten play) take on the Fighting Illini (3-1, 0-1) from Memorial Stadium in Champaign, Illinois, in an important Big Ten matchup. The Trojans are coming off a 45-31 win over Michigan State, while Illinois lost 63-10 to Indiana.

A win for the Trojans could continue the upward trajectory for a program still looking for its first College Football Playoff berth under coach Lincoln Riley. Conversely, a win for Bret Bielema and Illinois would mark a huge turnaround after the thrashing the Illini received at the hands of Indiana in Week 4.

Stream USC football vs. Illinois live on Fubo (free trial)

The Sept. 27 between the two teams is not only their first game since USC joined the Big Ten, but also the first meeting in over 17 years. Their last game occurred in the Rose Bowl on Jan. 1, 2008, when the Trojans were still a member of the former Pac-10 Conference. USC dominated in a 49-17 win, giving it an 11-2 all-time series lead.

Here's how to watch, including time, TV schedule, live streaming info and game odds:

What TV channel is USC vs Illinois on today?

  • TV: Fox
  • Streaming: Fox Sports App | Fubo (free trial)

USC vs. Illinois will air nationally on Fox in Week 5 of the 2025 college football season. The teams will play at Memorial Stadium in Champaign, Illinois, with Gus Johnson (play-by-play) and Joel Klatt (analyst) calling the game. Jenny Taft will serve as the sideline reporter.

Streaming options include the Fox Sports app and Fubo, the latter of which offers a free trial to potential subscribers.

USC vs Illinois time today

  • Date: Saturday, Sept. 27
  • Time: Noon ET (9 a.m. PT)

The Week 5 Big Ten matchup between USC football and Illinois is scheduled to start at noon ET (9 a.m. PT) on Saturday, Sept. 27.

USC vs Illinois predictions, picks, odds

  • Prediction: Illinois 35, USC 30

The Fighting Illini will bounce back from an embarrassing loss last week on the road to Indiana to reposition themselves for a potential CFP run.

Odds courtesy of BetMGM as of Tuesday, Sept. 23:

  • Spread: USC (-6.5)
  • Over/under: 59.5
  • Moneyline: USC (-250); Illinois (+200)

This article originally appeared on USA TODAY: What channel is USC vs Illinois on today? Time, TV schedule to watch Week 5 game

Reporting by Ehsan Kassim, USA TODAY NETWORK - Florida / USA TODAY

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