The Jacksonville Jaguars (2-1) and San Francisco 49ers (3-0) meet Sunday. Kickoff from Levi's Stadium in Santa Clara, California, is scheduled for 4:05 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the Jaguars vs. 49ers odds and make our expert NFL picks and predictions for the best bets.

The Jaguars are coming off a 17-10 win over the Houston Texans in Jacksonville in Week 3. They covered as 1.5-point favorites and the Under (43.5) hit. WR Brian Thomas Jr. had a crucial 46-yard gain that set up RB Travis Etienne ’s go-ahead TD run with 1:48 remaining. Jacksonville is 2-1 against the spread (ATS) this season.

The 49ers failed to cover as 2-point home favorites in a 16-15 win over the Arizona Cardinals in Week 3 as the Under (44.5) cashed. PK Eddy Pin

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