The start of the 2025 NFL season is being shaped by injuries to star players. Week 5 adds even more to the list. Miami Dolphins star wide receiver Tyreek Hill and New York Giants star receiver Malik Nabers are the headliners. Other names to watch include Bucky Irving, Ricky Pearsall, Lamar Jackson, Cedric Tillman, and Darnell Mooney. Teams now face the challenge of finding short-term answers.

NFL Week 5 Injuries: Key Losses and Potential Replacements

[caption id="attachment_249182" align="aligncenter" width="640"] Sep 28, 2025; East Rutherford, New Jersey, USA; New York Giants wide receiver Malik Nabers (1) is carted off the field following an injury during the second quarter against the Los Angeles Chargers at MetLife Stadium. Mandatory Credit: Brad Penner-Imagn Images[/caption]

Tyreek

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