Shaun Albin analyzes which defenses (DEF) to sit or start in Week 6 (2025) of the NFL season, and provides his best fantasy football streaming options.

Finding the right defense to stream each week can often be the difference between pulling out a close fantasy win or falling just short. Matchups, injuries, and team trends all play a massive role in determining which units are worth plugging into lineups. Week 6 brings several intriguing options, with a handful of defenses drawing favorable opponents who have struggled to move the ball or protect the quarterback.

The good news for fantasy managers is that multiple defenses sitting on waiver wires are in position to produce strong numbers this week. From teams facing turnover-prone quarterbacks to those taking on offenses that can’t seem

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