Early control of the NFC West will be on the line when the San Francisco 49ers take on the Los Angeles Rams on Thursday Night Football. San Francisco dropped a 26-21 decision to Jacksonville, while Los Angeles pulled out a 27-20 win over Indianapolis on Sunday. The Rams (3-1), who are 0-1 in the conference, are 2-0 on their home field this season. The 49ers (3-1), who are 3-0 in the conference, are 2-0 on the road. San Francisco quarterback Brock Purdy (toe) has been ruled out, along with Jauan Jennings (ankle, ribs) and Ricky Pearsall (knee).

Kickoff from SoFi Stadium in Inglewood, Calif., is set for 8:15 p.m. ET. The 49ers lead the all-time series 78-71-3, including wins in each of the last five meetings. After opening at -1.5, the Rams are now 8.5-point favorites in the latest 49er

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