The Detroit Lions (3-1) play against the Cincinnati Bengals (2-2) in Week 5 of the 2025 regular season. The Lions have won three straight games, including a 34-10 win over the Cleveland Browns last week. It's been tough for the Bengals since Joe Burrow went down with turf toe, as they've lost two consecutive games. On Sept. 29, the Broncos blew out Cincinnati 28-3. D.J. Reed (hamstring) is out for the Lions.

Kickoff is set for 4:25 p.m. ET from Paycor Stadium in Cincinnati. The Lions are favored by 10.5 points in the latest Lions vs. Bengals odds at DraftKings Sportsbook, while the over/under for total points scored is 49.5. The Lions are -550 money line favorites, while the Bengals are +410 underdogs. Before making any Lions vs. Bengals picks, make sure you check out the NFL picks from t

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