South Florida Bulls quarterback Byrum Brown (17) before the game against the South Carolina State Bulldogs at Raymond James Stadium in Tampa, Florida.

The Charlotte 49ers (1-3, 0-1 American) visit the USF Bulls (3-1, 0-0) Friday at Raymond James Stadium in Tampa, Florida. Kickoff is scheduled for 7 p.m. ET (ESPN2). Let's analyze BetMGM Sportsbook's NCAA football odds around the Charlotte vs. USF odds and make our expert college football picks and predictions for the best bets.

Charlotte dropped its third game of the season Sept. 18, falling 28-17 to Rice and failing to cover as a 2.5-point home underdog. QB Grayson Loftis threw for 186 yards and a touchdown, with WR Javen Nicholas (5 receptions, 93 yards, 1 TD) serving as his top target.

USF returned to the win column Sept. 20 with a 63-14 rout of South Carolina State, covering as a 36-point home favorite. QB Byrum Brown went 14-of-20 for 236 yards with 4 TDs and an interception, while RB Sam Franklin dominated on the ground with 4 carries for 92 yards and 2 TDs.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

Charlotte at USF odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 6:37 p.m. ET.

  • Moneyline (ML): Charlotte +1850 (bet $100 to win $1,850) | USF -10000 (bet $10,000 to win $100)
  • Against the spread (ATS): Charlotte +27.5 (-105) | USF -27.5 (-115)
  • Over/Under (O/U): 54.5 (O: -115 | U: -105)

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Charlotte at USF picks and predictions

Prediction

USF 41, Charlotte 10

Moneyline

PASS.

There is no value on USF (-10000) to win at home Friday.

Against the spread

LEAN USF -27.5 (-115).

USF has displayed its dominance on the ground this season, as demonstrated against South Carolina State, where 3 different players each rushed for at least 48 yards on just 4 carries. While Brown is a force under center, the Bulls' offense is too strong for the 49ers to contain, boasting an average home win margin of 38 points this season.

The 49ers have struggled, scoring 17 or fewer points in 3 of their 4 games and failing to cover in each of their 3 contests as underdogs. Friday will also mark their first road game of the season.

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Over/Under

BET UNDER 54.5 (-105).

The Bulls will dominate this matchup, carrying most of the offensive load. The 49ers do not have the firepower to put up the points needed to hit the Over. Their last game against Rice totaled just 45 points, despite the Over hitting.

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This article originally appeared on Sportsbook Wire: Charlotte 49ers at USF Bulls odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

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