Acetaminophen—What You Need to Consider

Acetaminophen recently became a polarizing political topic and target. It's important to remove the political filters and pull the lens back to see acetaminophen for what it actually is—a synthetic chemical that has no clear nonsynthetic biologic analogs or receptors—and what that means for the human organism outside of politics .

Acetaminophen was first synthesized in 1887 in a U.S. university laboratory by the reduction of p-nitrophenol with tin in glacial acetic acid. In 1893, the first clinical trials using acetaminophen were conducted but discontinued due to severe and serious side effects. In the 1940s, acetaminophen was revived as an alternative to and a less toxic metabolite of the compounded drugs acetanilide and phenacetin, which had been associated with blood cell disorders,