Sep 6, 2025; Boulder, Colorado, USA; Delaware Fightin Blue Hens quarterback Nick Minicucci (4) prepares to pass the ball in the second half against the Colorado Buffaloes at Folsom Field. Mandatory Credit: Ron Chenoy-Imagn Images

We begin the Friday college football slate in Week 6 with an intriguing Conference USA showdown.

The Western Kentucky Hilltoppers travel to Newark, Delaware, to face the Delaware Blue Hens, a new FBS addition in 2025. Despite being a newcomer to the conference, the Blue Hens have impressed so far. They are 3-1 with wins against UConn and in their CUSA opener last week against Florida International.

The Hilltoppers, meanwhile, were a preseason favorite in this league and are 2-0 to begin conference play. WKU took down Sam Houston in Week 1 before beating the other FBS newcomer, Missouri State, in Week 5.

Stream Delaware vs. Western Kentucky

If you are looking for betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Delaware vs. Western Kentucky game odds

All college football odds via BetMGM

  • Spread: Delaware -2.5 (-115), WKU +2.5 (-105)
  • Money line: Delaware -145, WKU +120
  • Over/Under: Over 61.5 (-115), Under 61.5 (-105)

Delaware vs. Western Kentucky prediction, pick:

The Blue Hens have impressed so far since moving up from the FCS, and they're a slim favorite at home. However, this will be toughest test of the season aside from their game against Colorado, which was a blowout win for the Buffaloes.

The Hilltoppers are just the better team right now.

Prediction: Western Kentucky 34, Delaware 27

Best Bet: WKU +2.5, Under 61.5

New Mexico State vs. Sam Houston channel, start time, streaming:

Time: 7 p.m. ET

TV Channel: CBS Sports Network

Live Stream: Paramount+

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Delaware vs. Western Kentucky: Week 6 college football betting odds, prediction, pick

Reporting by Tyler Nettuno, College Sports Wire / College Sports Wire

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