A disappointing home loss to now-No. 2 Oregon dropped the Penn State Nittany Lions down the AP rankings.

They have an opportunity this week to unleash their frustration on a winless UCLA Bruins squad that is falling apart.

The Nittany Lions (-2400) are sizable 24.5-point spread favorites over UCLA (+1400) on the road, while the point total rests around 49.5 points.

Look below to find our Penn State vs. UCLA predictions, picks, and best bets ahead of this Big Ten matchup on Saturday.

Penn State vs. UCLA Predictions and best bets

Penn State Nittany Lions -24.5: -105 at Caesars

Over 49.5 points: -108 at DraftKings

*Note: Odds are based on the best value our experts find as of publication; check lines closer to game time to ensure you get the best odds.

Penn State Nittany Lions -

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