The New Orleans Saints will continue the quest for their first win of the 2025 season when they host the New York Giants in NFL Week 5 on Paramount+ . Spencer Rattler and the Saints tried to keep up with the Bills in Week 4, but ultimately fell 31-19 in Buffalo. Meanwhile, the Giants secured their first win of the season in Week 4 with a hard-fought 21-18 win against the Los Angeles Chargers in Jaxson Dart's professional debut.

Kickoff from Caesars Superdome is set for 1 p.m. ET on CBS and Paramount+ . New Orleans is a 1.5-point favorite in the latest Giants vs. Saints odds from SportsLine consensus, while the over/under for total points scored is 42. Before making any Saints vs. Giants picks, make sure you check out the picks from the SportsLine Projection Model. Be sure to watch

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