The Buffalo Bills look to stay unbeaten and take control of the AFC East when they take on the New England Patriots on Sunday Night Football. Buffalo is coming off a 31-19 win over the New Orleans Saints , while New England rolled to a 42-13 win over the Carolina Panthers in Week 4. The Patriots (2-2), who are 1-0 within the division, are also 1-0 on the road in 2025. The Bills (4-0), who are 2-0 in the division, are 3-0 on their home field. Buffalo has also won four straight home games versus New England.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 8:20 p.m. ET. The Patriots lead the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings. Buffalo is a 7.5-point favorite in the latest Patriots vs. Bills odds from SportsLine consensus, whi

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